Diazepam Impurity 8 CAS 784-38-3
| CAS No. | 784-38-3 |
| Molecular Formula | C13H9ClFNO |
| Molecular Weight | 249.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Diazepam Impurity 8 (CAS 784-38-3, C13H9ClFNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C13H9ClFNO, Diazepam Impurity 8 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 249.67 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H9ClFNO |
| Molecular Weight | 249.67 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Diazepam Standards
- Diazepam EP Impurity D (CAS 1022-13-5)
- Diazepam Impurity 11 (CAS CATO-C4X-146511)
- Diazepam Impurity 11 (CAS 5606-40-6)
- 【禁售不询】Diazepam EP impurity A (CAS 1088-11-5)
- Diazepam EP Impurity E (CAS 20927-53-1)
- Diazepam Impurity 12 (CAS CATO-C4X-146512)
- Diazepam Impurity 10 (CAS CATO-C4X-146510)
- Diazepam (CAS 439-14-5)
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