Sildenafil Impurity 59 CAS 792969-85-8
| CAS No. | 792969-85-8 |
| Molecular Formula | C8H12N4O3 |
| Molecular Weight | 212.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 212.21 g/mol gives Sildenafil Impurity 59 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Sildenafil Impurity 59 (CAS 792969-85-8) is a certified pharmaceutical impurity reference standard with the molecular formula C8H12N4O3 and a molecular weight of 212.21 g/mol.
Sildenafil Impurity 59 (C8H12N4O3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H12N4O3 |
| Molecular Weight | 212.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Nitrogen Atoms | 4 |
Related Sildenafil Standards
- Sildenafil Impurity 35 (CAS 139756-01-7)
- Sildenafil Impurity N23 (CAS 247583-72-8)
- Sildenafil Impurity 41 (CAS 304435-83-4)
- Sildenafil RC 41 (CAS 222729-55-7)
- Sildenafil Impurity 36 (CAS 139756-00-6)
- Sildenafil RC 39 (CAS 1346605-36-4)
- Sildenafil Impurity 274 (CAS 1358966-40-1)
- Sildenafil Impurity 56 (CAS CATO-C4X-112856)
Recommended Standards
- Pentoxifylline Impurity 9 (CAS 1597448-45-7)
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- Fluconazole EP Impurity C (CAS 514222-44-7)
- Rivaroxaban Impurity 70 (CAS 1384257-81-1)
- Faropenem Impurity 81 (CAS CATO-C4X-128981)
- Salicylic acid impurity 30 (CAS 2704-58-7)
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