Resmetirom impurity 134 CAS 28165-63-1
| CAS No. | 28165-63-1 |
| Molecular Formula | C6H5Cl2NO |
| Molecular Weight | 178.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 178.02 g/mol gives Resmetirom impurity 134 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Resmetirom impurity 134 (CAS 28165-63-1), a pharmacopoeial impurity reference standard (molecular formula C6H5Cl2NO, MW 178.02 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Resmetirom impurity 134 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 178.02 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H5Cl2NO |
| Molecular Weight | 178.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Resmetirom Standards
- Resmetirom impurity 64 (CAS 2375196-15-7)
- Resmetirom impurity 65 (CAS 1696366-11-6)
- Resmetirom Impurity 4 (CAS 107228-51-3)
- Resmetirom Impurity 45 (CAS CATO-C4X-291245)
- Resmetirom impurity 133 (CAS 1314924-95-2)
- Resmetirom impurity 135 (CAS 3096249-74-7)
- Resmetirom Impurity 3 (CAS 6629-04-5)
- Resmetirom Impurity 44 (CAS CATO-C4X-291244)
Recommended Standards
- Lenvatinib Impurity 129 (CAS 26271-75-0)
- 4-Amino-2,6-dichlorophenol (CAS 5930-28-9)
- O-(3,5-Dichlorophenyl)hydroxylamine (CAS 99907-90-1)
- 1-Azido-4-bromobutane (CAS 116114-55-7)
- Bortezomib Impurity 44 (CAS 78-77-3)
- Methyl Salicylate EP Impurity J (CAS 22717-57-3)
- Dotinurad Impurity 25 (CAS 2142685-21-8)
- 5-Chloro-2-(piperazin-1-yl)thiazole (CAS 223514-52-1)
- Frangufoline (CAS 19526-09-1)
- 5-Bromo-6-hydroxy-2,3-dihydro-1H-inden-1-one (CAS 622835-34-1)
- 2-ethynyloxetane (CAS 33869-43-1)
- 2-Bromo-4-(trifluoromethyl)benzenethiol (CAS 59594-65-9)
- 1-Methyl-2-oxo-1,2-dihydroquinoline-4-carbaldehyde (CAS 15112-98-8)
- Angiotensin II Antipeptide (CAS 121379-63-3)
Why CATO?
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