Temozolomide Impurity 25 CAS 83-01-2
| CAS No. | 83-01-2 |
| Molecular Formula | C13H10ClNO |
| Molecular Weight | 231.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Temozolomide Impurity 25 (CAS 83-01-2, C13H10ClNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Temozolomide Impurity 25 (C13H10ClNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Temozolomide Impurity 25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H10ClNO |
| Molecular Weight | 231.68 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Temozolomide Standards
- Temozolomide Impurity 26 (CAS 13114-72-2)
- Temozolomide Impurity 2 (CAS 287964-59-4)
- Temozolomide Impurity 15 (CAS 100607-08-7)
- Temozolomide-d3 (CAS 208107-14-6)
- Temozolomide EP Impurity B (CAS 113942-30-6)
- Temozolomide Impurity 19 (CAS CATO-C4X-135319)
- Temozolomide Impurity 3 (CAS 188612-53-5)
- Temozolomide EP Impurity C (CAS 114601-31-9)
Recommended Standards
- Ezetimibe Impurity 50 (CAS 3369-35-5)
- Alprazolam EP Impurity E (CAS 719-59-5)
- (4-aminophenyl)(4-chlorophenyl)methanone 4-Amino-4'-chlorobenzophenone 4913-77-3 (CAS 4913-77-3)
- Urapidil Impurity 3 (CAS 34654-81-4)
- Fosfomycin Impurity 63 (CAS CATO-C4X-131663)
- Baricitinib Impurity 105 (CAS CATO-C4X-2260105)
- Pitavastatin Impurity 71 (CAS CATO-C4X-103771)
- (S)-1-(5-chloro-2-(trifluoromethyl)phenyl)ethan-1-amine (CAS 1259858-75-7)
- Landiolol Impurity 98 HCl (CAS CATO-C4X-262198)
- Trihexadecyl(phenyl)silane (CAS 18822-36-1)
- 1-{[2-(4-bromophenoxy)-1,3-thiazol-5-yl]methyl}-1H-indole (CAS 439097-11-7)
- 2-(2-Bromophenyl)-9-phenyl-9H-carbazole (CAS 1616607-88-5)
- 6-Phenylhex-5-en-2-ol (CAS 58927-89-2)
- Protein Kinase C (19-36) Peptide (CAS 113731-96-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com