Crizotinib Impurity 63 ·x p-Toluenesulfonic acid CAS 2059996-30-2
| CAS No. | 2059996-30-2 |
| Molecular Formula | C26H30Cl2FN5O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Crizotinib Impurity 63 ·x p-Toluenesulfonic acid (CAS 2059996-30-2), a pharmacopoeial impurity reference standard (molecular formula C26H30Cl2FN5O3·xC7H8O3S, MW 722.65 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Crizotinib Impurity 63 ·x p-Toluenesulfonic acid is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 722.65 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Crizotinib Impurity 63 ·x p-Toluenesulfonic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H30Cl2FN5O3 ·xC7H8O3S |
| Molecular Weight | 722.65 g/mol |
| Purity | ≥98% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Crizotinib Standards
- Crizotinib impurity 15 (CAS 1175708-03-8)
- Crizotinib Impurity 8 (CAS 1233484-06-4)
- Crizotinib impurity 11 (CAS 1269429-29-9)
- Crizotinib S-Isomer (CAS 1374356-45-2)
- Crizotinib-d5 (CAS 1395950-48-7)
- Crizotinib-d5 (CAS 1395950-84-1)
- Crizotinib Impurity N12 (CAS 1401697-46-8)
- Crizotinib 2-Keto Impurity (CAS 1415558-82-5)
Recommended Standards
- Metronidazole Impurity 25 (CAS 16156-93-7)
- Fluralaner Impurity 49 (CAS CATO-C4X-218049)
- Cyproterone Acetate EP Impurity C (CAS 17183-98-1)
- 2-Bromo-1-(1H-pyrrol-2-yl)propan-1-one (CAS 854667-34-8)
- (S)-2-(1H-Imidazol-1-yl)propan-1-ol (CAS 497830-17-8)
- N-(3,4-Dichlorophenyl)tetrahydrofuran-2-carboxamide (CAS 545340-98-5)
- Tert-butyl (2-(5-mercapto-1,3,4-oxadiazol-2-yl)ethyl)carbamate (CAS 843619-52-3)
- 3-(2,4-Dichlorophenyl)propanoic acid (CAS 55144-92-8)
- 2-(1-Aminocyclopropyl)acetic acid (CAS 133616-20-3)
- Peptide Impurity 81 TFA (CAS CATO-CPTD788581)
Why CATO?
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