Cabozantinib Impurity N3 CAS 651054-52-3
| CAS No. | 651054-52-3 |
| Molecular Formula | C19H18N2O4 |
| Molecular Weight | 338.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Cabozantinib Impurity N3 (CAS 651054-52-3) is a certified pharmaceutical impurity reference standard with the molecular formula C19H18N2O4 and a molecular weight of 338.36 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Cabozantinib Impurity N3 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 338.36 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Cabozantinib Impurity N3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H18N2O4 |
| Molecular Weight | 338.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 2 |
Related Cabozantinib Standards
- Cabozantinib Impurity 50 (CAS CATO-C4X-201850)
- Cabozantinib Impurity 23 (CAS CATO-C4X-201823)
- Cabozantinib Impurity 2 (CAS 190728-24-6)
- Cabozantinib Impurity 48 (CAS CATO-C4X-201848)
- Cabozantinib Impurity 3 (CAS 1431468-36-8)
- Cabozantinib Impurity 5 (CAS 849217-60-3)
- Cabozantinib Impurity 42 (CAS CATO-C4X-201842)
- Cabozantinib Impurity 8 (CAS 213699-53-7)
Recommended Standards
- 6-Butyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-methyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one (CAS 89889-84-9)
- Cimoxatone (CAS 73815-11-9)
- 6-Benzyl-3-((2,4-dimethoxyphenyl)amino)-1,2,4-triazin-5(4H)-one (CAS 534597-95-0)
- Diethyl 3-(1H-indol-4-yl)pyridine-2,5-dicarboxylate (CAS 653573-24-1)
- Empagliflozin impurity 185 (CAS CATO-C4X-1065185)
- Salmeterol EP Impurity B (CAS 94749-02-7)
- Tirzepatide Impurity 48 (CAS CATO-C4X-324048)
- 3-((2R,3S)-1-(tert-butoxycarbonyl)-3-((tert-butyldimethylsilyl)oxy)piperidin-2-yl)propanoic acid (CAS 2241812-35-9)
- (3,4-Difluorophenyl)(2-(methylthio)phenyl)methanone (CAS 951888-21-4)
- 2,2,2-Trifluoro-N-(thiazol-4-yl)acetamide (CAS 59134-92-8)
- Tetrahydropyranyldiethyleneglycol (CAS 2163-11-3)
- 6-N-Biotinylaminohexyl Isopropyl Phosphorofluoridate, Hemihydrate (CAS 353754-93-5)
- Tert-butyl 3-(3-methyl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (CAS 1243306-92-4)
- Semaglutide impurity 47 (CAS CATO-C4X-222647)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com