Chlorpheniramine Impurity 32 CAS 854863-55-1
| CAS No. | 854863-55-1 |
| Molecular Formula | C12H15ClN2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 259.17 g/mol gives Chlorpheniramine Impurity 32 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Chlorpheniramine Impurity 32 (CAS 854863-55-1) is a certified pharmaceutical impurity reference standard with the molecular formula C12H15ClN2HCl and a molecular weight of 259.17 g/mol.
The molecular framework of Chlorpheniramine Impurity 32 (C12H15ClN2HCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Chlorpheniramine Impurity 32 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H15ClN2 HCl |
| Molecular Weight | 259.17 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlorpheniramine Standards
- Chlorpheniramine Impurity 41 (CAS 101286-08-2)
- Chlorpheniramine Maleate (CAS 113-92-8)
- Chlorpheniramine-d6 (CAS 1185054-60-7)
- Chlorpheniramine Impurity 15 (CAS 120244-82-8)
- Chlorpheniramine-d6 Maleate Salt (CAS 1219806-45-7)
- Chlorpheniramine (CAS 132-22-9)
- Chlorpheniramine Nitrile-d6 (CAS 1329488-38-1)
- R-Chlorpheniramine N-Oxide (CAS 142494-45-9)
Recommended Standards
- Vonoprazan Impurity 160 (CAS 2514735-12-5)
- Topiroxostat Impurity 7 (CAS 2044704-74-5)
- Sultamicillin Tosilate Dihydrate EP Impurity D (CAS CATO-C4X-188616)
- Methyl 2,4-dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (CAS 1004294-98-7)
- 4-((Cyclopropylamino)methyl)benzonitrile (CAS 953903-93-0)
- 2-Bromo-5-methoxy-3-methyl-1H-indole (CAS 1785580-34-8)
- 2-Chloro-1-(3-chloro-2-methylphenyl)-2,2-difluoroethan-1-one (CAS 1352222-04-8)
- N-((1H-Benzo[d][1,2,3]triazol-1-yl)methyl)-N-benzylaniline (CAS 146041-86-3)
- 5-Methoxy-1-methyl-1,6-dihydropyridin-3(2H)-one (CAS 66310-87-0)
- Semaglutide impurity 106 (CAS CATO-C4X-2226106)
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