Hydroxychloroquine EP Impurity G CAS 86-98-6
| CAS No. | 86-98-6 |
| Molecular Formula | C9H5Cl2N |
| Molecular Weight | 198.05 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Hydroxychloroquine EP Impurity G (CAS 86-98-6) is a certified pharmaceutical impurity reference standard with the molecular formula C9H5Cl2N and a molecular weight of 198.05 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Hydroxychloroquine EP Impurity G is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 198.05 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Hydroxychloroquine EP Impurity G meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H5Cl2N |
| Molecular Weight | 198.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Hydroxychloroquine Standards
- Hydroxychloroquine Impurity 11 (CAS 21617-12-9)
- Hydroxychloroquine Impurity N54 (CAS 5448-52-2)
- Hydroxychloroquine impurity 87 (CAS CATO-C4X-183587)
- Hydroxychloroquine Impurity 54 (CAS 880-09-1)
- Hydroxychloroquine Impurity 30 (CAS 1077-74-3)
- Hydroxychloroquine Impurity 10 (CAS 86-99-7)
- Hydroxychloroquine Impurity 68 (CAS 23443-05-2)
- Hydroxychloroquine Impurity 23 (CAS 69559-11-1)
Recommended Standards
- 4,5-Dichloroquinoline (CAS 21617-18-5)
- 3-Bromo-5-cyclopropylpyridine (CAS 1044210-57-2)
- 628-17-1 1-Iodopentane Pentane, 1-iodo- Amyl iodide n-Amyl iodide EINECS 211-030-0 1-Jodpentan [Czech] NSC 7901 Pentyl iodide n-Pentyl iodide 1-Pentyl iodide 1-Jodpentan (CAS 628-17-1)
- 2-Bromo-6-cyclopropylpyridine (CAS 1086381-26-1)
- Dapoxetine Impurity 81 (CAS 2415108-74-4)
- Labetalol Impurity 62 (CAS CATO-C4X-246662)
- Bupivacaine Hydrochloride EP Impurity E (CAS CATO-C4X-148236)
- 3-Methanesulfonylprop-2-enenitrile (CAS 131391-67-8)
- Methyl 3-amino-5-chloro-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate (CAS 841261-58-3)
- 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl (CAS 145757-47-7)
- (5-(Trifluoromethyl)-2-(trimethylsilyl)phenyl)boronic acid (CAS 1257792-96-3)
- 2-(5-(Trifluoromethoxy)-1H-indol-3-yl)acetic acid (CAS 27269-41-6)
- (3R,4R)-4-fluoro-1-methylpiperidin-3-amine (CAS 2306246-12-6)
- Liraglutide (CAS 204656-20-2)
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