Hydroxychloroquine Impurity 10 CAS 86-99-7
| CAS No. | 86-99-7 |
| Molecular Formula | C9H6ClNO |
| Molecular Weight | 179.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Hydroxychloroquine Impurity 10 (C9H6ClNO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 179.60 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Hydroxychloroquine Impurity 10 (CAS 86-99-7) is a certified pharmaceutical impurity reference standard with the molecular formula C9H6ClNO and a molecular weight of 179.60 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Hydroxychloroquine Impurity 10 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H6ClNO |
| Molecular Weight | 179.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Hydroxychloroquine Standards
- Hydroxychloroquine Impurity 68 (CAS 23443-05-2)
- Hydroxychloroquine Impurity 54 (CAS 880-09-1)
- Hydroxychloroquine Impurity 23 (CAS 69559-11-1)
- Hydroxychloroquine impurity 80 (CAS CATO-C4X-183580)
- Hydroxychloroquine Impurity 33 (CAS 74509-79-8)
- Hydroxychloroquine Impurity 11 (CAS 21617-12-9)
- Hydroxychloroquine EP Impurity G (CAS 86-98-6)
- Hydroxychloroquine Impurity 18 (CAS 140-80-7)
Recommended Standards
- Ketoprofen Impurity 112 (CAS 42872-32-2)
- Famotidine impurity 74 (CAS 90224-97-8)
- 5-Chloro-8-hydroxyquinoline (CAS 130-16-5)
- Isavuconazole Impurity 86 (CAS 40805-50-3)
- Chlorphenamine Impurity 7 (CAS 78180-89-9)
- Sumatriptan aminophenyl Impurity C05 (CAS 109903-35-7)
- Ruxolitinib Impurity 131 (CAS CATO-C4X-2058131)
- 2-bromo-N-(2,3-dihydro-1,4-benzodioxin-6-yl)butanamide (CAS 347342-54-5)
- Vildagliptin Impurity 6 (CAS 1789703-36-1)
- 1-(2,6-Dichlorophenyl)-3-(o-tolyl)propan-1-one (CAS 898790-20-0)
- 5-Ethyl-1-(2-hydroxyethyl)-1h-1,2,3-triazole-4-carboxylic acid (CAS 1267394-06-8)
- 4-Hydroxy-N-(4-methoxyphenyl)benzene-1-sulfonamide (CAS 380341-92-4)
- 2-Methyl-3-(pyrrolidin-1-yl)propanoic acid (CAS 875255-88-2)
- Semaglutide Impurity 140 (CAS CATO-C4X-2226140)
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