Trametinib impurity 7 CAS 871700-22-0
| CAS No. | 871700-22-0 |
| Molecular Formula | C14H15FIN3O2 |
| Molecular Weight | 403.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Trametinib impurity 7 (C14H15FIN3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Trametinib impurity 7 (CAS 871700-22-0) is a certified pharmaceutical impurity reference standard with the molecular formula C14H15FIN3O2 and a molecular weight of 403.19 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Trametinib impurity 7 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H15FIN3O2 |
| Molecular Weight | 403.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 3 |
Related Trametinib Standards
- Trametinib Impurity 1 (CAS 871700-28-6)
- Trametinib impurity 8 (CAS 871700-26-4)
- Trametinib Impurity N9 (CAS 871700-41-3)
- Trametinib impurity 11 (CAS CATO-C4X-278211)
- Trametinib impurity 12 (CAS 3018911-27-5)
- Trametinib impurity 03 (CAS 871700-24-2)
- Trametinib Impurity 16 (CAS CATO-C4X-278216)
- Trametinib Impurity N1 (CAS 329941-39-1)
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- Nifedipine Impurity 21 (CAS 80742-13-8)
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- 2-Amino-2-(2,5-dichlorophenyl)ethanol hydrochloride (CAS 2411638-49-6)
- 6-Bromo-1H-indazole-5-carboxylic acid methyl ester (CAS 1396762-16-5)
- 1-(4-Methyl-4H-1,2,4-triazol-3-yl)ethanamine hydrochloride (CAS 1559059-85-6)
- Renin Inhibitor Peptide (CAS 50410-01-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com