Trametinib impurity 03 CAS 871700-24-2
| CAS No. | 871700-24-2 |
| Molecular Formula | C18H15FIN3O4 |
| Molecular Weight | 483.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 483.23 g/mol gives Trametinib impurity 03 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Trametinib impurity 03 (CAS 871700-24-2) is a certified pharmaceutical impurity reference standard with the molecular formula C18H15FIN3O4 and a molecular weight of 483.23 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution, Trametinib impurity 03 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 483.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H15FIN3O4 |
| Molecular Weight | 483.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 3 |
Related Trametinib Standards
- Trametinib Impurity 16 (CAS CATO-C4X-278216)
- Trametinib impurity 12 (CAS 3018911-27-5)
- Trametinib impurity 14 (CAS CATO-C4X-278214)
- Trametinib impurity 7 (CAS 871700-22-0)
- Trametinib impurity 01 (CAS 871701-87-0)
- Trametinib impurity 5 (CAS CATO-C4X-27825)
- Trametinib Impurity 1 (CAS 871700-28-6)
- Trametinib impurity 8 (CAS 871700-26-4)
Recommended Standards
- 2'-Deoxycytidine-5'-O-(1-thiotriphosphate) (CAS 64145-29-5)
- Tetra-p-tolyltin (CAS 6746-22-1)
- Methyl 7-bromo-2-oxo-8-(piperidin-1-ylmethyl)-2H-selenopheno[3,2-h]chromene-3-carboxylate (CAS 2173398-14-4)
- Ethyl 4-([(4-formyl-2-iodo-6-methoxyphenoxy)acetyl]amino)benzoate (CAS 832674-64-3)
- Amiodarone Hydrochloride EP Impurity H (CAS 869-24-9)
- Mesna EP Impurity B (CAS 1391053-66-9)
- Dexrazoxane Impurity 31 (CAS 75459-34-6)
- Hexanedioic acid, polymer with 1,2-ethanediol and 2,5-furandione, 2-ethylhexanoate (CAS 65970-51-6)
- 3-Amino-2-(p-tolyl)propanoic acid hydrochloride (CAS 2201551-71-3)
- 3-(Benzylsulfonyl)azetidine hydrochloride (CAS 1864064-19-6)
- 5-(Aminomethyl)-3-ethyloctan-4-ol (CAS 1540675-17-9)
- Tert-butyl 4-(3-amino-2-methylpropanoyl)piperazine-1-carboxylate (CAS 1303889-86-2)
- n-Butylbenzene-2,3,4,5,6-d5 (CAS 20329-91-3)
- Endo-38a-Pro-Exenatide trifluoroacetate salt (CAS 1678416-95-9)
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