Trametinib impurity 12 CAS 3018911-27-5
| CAS No. | 3018911-27-5 |
| Molecular Formula | C17H17FIN3O3 |
| Molecular Weight | 457.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Trametinib impurity 12.
CATO supplies Trametinib impurity 12 (CAS 3018911-27-5), a pharmacopoeial impurity reference standard (molecular formula C17H17FIN3O3, MW 457.24 g/mol) used for the identification and quantification of trace impurities in APIs.
Trametinib impurity 12 (C17H17FIN3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Trametinib impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H17FIN3O3 |
| Molecular Weight | 457.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 3 |
Related Trametinib Standards
- Trametinib impurity 03 (CAS 871700-24-2)
- Trametinib Impurity 16 (CAS CATO-C4X-278216)
- Trametinib impurity 7 (CAS 871700-22-0)
- Trametinib impurity 14 (CAS CATO-C4X-278214)
- Trametinib Impurity 1 (CAS 871700-28-6)
- Trametinib impurity 8 (CAS 871700-26-4)
- Trametinib Impurity N9 (CAS 871700-41-3)
- Trametinib impurity 11 (CAS CATO-C4X-278211)
Recommended Standards
- 8-Chloro-5-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one (CAS 303986-22-3)
- (7-Bromo-9,9-dihexyl-9H-fluoren-2-yl)boronic acid (CAS 934762-26-2)
- Guanosine Impurity 3 (CAS 117723-13-4)
- 2-Bromo-3-dodecyl-5-iodothiophene (stabilized with Copper chip) (CAS 306769-48-2)
- Econazole Impurity 13 (CAS 88965-93-9)
- Venlafaxine Impurity 58 (CAS 1000377-27-4)
- Dotinurad Impurity 160 (CAS CATO-C4X-2494160)
- 1-(3,4-Difluorobenzyl)-4-bromo-1H-pyrazole (CAS 1545587-66-3)
- 4-Amylpyridine (CAS 2961-50-4)
- 2-(3,5-Dimethyl-1,1-dioxo-2h-1,2,6-thiadiazin-4-yl)acetic acid (CAS 872107-98-7)
- N-((2-Bromopyridin-4-yl)methyl)-2-chloroacetamide (CAS 1353978-11-6)
- 3-Ethyl-6,7,8,9-tetrahydropyrazolo[3,4-d]pyrido[1,2-a]pyrimidin-4(1H)-one (CAS 1707668-13-0)
- 1-(5-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)naphthalen-1-yl)ethanone (CAS 244014-72-0)
- RGD-targeted Proapoptotic Peptide trifluoroacetate salt (CAS 2243207-09-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com