Nicorandil Impurity 3 DiHCl（Nicorandil EP Impurity C DiHCl） CAS 87330-70-9

Purity >90%In StockPharmacopoeial Impurity Standards
CAS No.87330-70-9
Molecular FormulaC8H10N2O2
Molecular WeightN/A
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Nicorandil Impurity 3 DiHCl（Nicorandil EP Impurity C DiHCl） CAS 87330-70-9 chemical structure

Description

The occurrence of Nicorandil Impurity 3 DiHCl（Nicorandil EP Impurity C DiHCl） is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

CATO supplies Nicorandil Impurity 3 DiHCl（Nicorandil EP Impurity C DiHCl） (CAS 87330-70-9), a pharmacopoeial impurity reference standard (molecular formula C8H10N2O2HCl, MW 202.64 g/mol) used for the identification and quantification of trace impurities in APIs.

Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Nicorandil Impurity 3 DiHCl（Nicorandil EP Impurity C DiHCl） is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 202.64 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC8H10N2O2 2*HCl
Molecular Weight202.64 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor)
Purity>90%
StorageStore at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)4.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1981
Halogen ContentCl-containing
Nitrogen Atoms2

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