Trandolapril Impurity 11 CAS 87679-38-7
| CAS No. | 87679-38-7 |
| Molecular Formula | C16H21NO2 |
| Molecular Weight | 259.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Trandolapril Impurity 11.
As a process- or degradation-related impurity, Trandolapril Impurity 11 (CAS 87679-38-7, C16H21NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Trandolapril Impurity 11 (C16H21NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 259.34 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H21NO2 |
| Molecular Weight | 259.34 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Nitrogen Atoms | 1 |
Related Trandolapril Standards
- Trandolapril Impurity 3 (2S,3aR,7aS) (CAS 144540-71-6)
- Trandolapril Impurity 10 (CAS 83508-14-9)
- Trandolapril Impurity 15 (CAS 760916-37-8)
- Trandolapril Impurity 7 (CAS CATO-C4X-17707)
- Trandolapril Impurity 8 (CAS CATO-C4X-17708)
- Trandolapril Impurity 14 (CAS CATO-C4X-177014)
- Trandolapril EP Impurity E (Trandolaprilate) (CAS 87679-71-8)
- Trandolapril EP Impurity D (CAS 149881-40-3)
Recommended Standards
- α-(4-Biphenylyl)Benzylamine (CAS 91487-88-6)
- Bifonazole impurity 11 (CAS 73842-48-5)
- Amorolfine Impurity 38 (CAS CATO-C4X-154238)
- Ibandronic Impurity 19 (CAS CATO-C4X-224419)
- EzetimiBe Impurity 19 (CAS 1391053-63-6)
- Famotidine Impurity 88 (CAS CATO-C4X-139288)
- Baclofen Impurity 38 (CAS CATO-C4X-101238)
- N4,N4,N4',N4'-Tetra(pyridin-2-yl)-[1,1'-biphenyl]-4,4'-diamine (CAS 154925-56-1)
- 1-O,2-O,3-O,4-O-Bis(1-methylethylidene)-6-deoxy-L-arabino-5-hexenopyranose (CAS 22618-03-7)
- (S)-1-(1-Phenylethyl)-1-(3-(triethoxysilyl)propyl)urea (CAS 68959-21-7)
- N4-(2-Fluorophenyl)-2-(3-methylpiperidin-1-yl)-5-nitropyrimidine-4,6-diamine (CAS 713126-62-6)
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- 4-(3-Ethyl-1,2,4-oxadiazol-5-yl)benzonitrile (CAS 1421262-65-8)
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