Siponimod Impurity 7 CAS 877131-37-8

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.877131-37-8
Molecular FormulaC15H25BrOSi
Molecular Weight329.35 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Siponimod Impurity 7 CAS 877131-37-8 chemical structure

Description

CATO supplies Siponimod Impurity 7 (CAS 877131-37-8), a pharmacopoeial impurity reference standard (molecular formula C15H25BrOSi, MW 329.35 g/mol) used for the identification and quantification of trace impurities in APIs.

The molecular framework of Siponimod Impurity 7 (C15H25BrOSi) is characterized by a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), Siponimod Impurity 7 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC15H25BrOSi
Molecular Weight329.35 g/mol
Purity97%+
StorageStore at room temperature
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure
Degree of Unsaturation (DBE)3.0
UV AbsorptionUV-absorbing
CAS Registry Year (est.)1987
Halogen ContentBr-containing

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