Famotidine Impurity 78 CAS 88068-99-9
| CAS No. | 88068-99-9 |
| Molecular Formula | C3H7ClN2O3S |
| Molecular Weight | 186.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Famotidine Impurity 78 (C3H7ClN2O3S) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 1.0, corresponding to approximately 1 ring(s) or double-bond equivalent(s). With a molecular weight of 186.62 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Famotidine Impurity 78 (CAS 88068-99-9, C3H7ClN2O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C3H7ClN2O3S |
| Molecular Weight | 186.62 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Famotidine Standards
- Famotidine Impurity 79 (CAS CATO-C4X-139279)
- Famotidine Impurity 45 (CAS 1644079-90-2)
- Famotidine Impurity 54 (CAS CATO-C4X-139254)
- Famotidine impurity 63 (CAS CATO-C4X-139263)
- Famotidine Impurity 50 (CAS 95853-51-3)
- Famotidine Impurity 02 (CAS 81152-53-6)
- Famotidine Impurity 27 (CAS 1378820-83-7)
- Famotidine Impurity 39 (CAS CATO-C4X-139239)
Recommended Standards
- 7-Chlorothieno[3,4-d]pyrimidin-4(3H)-one (CAS 53826-83-8)
- 7-Chloro-5H-thiazolo[3,2-a]pyrimidin-5-one (CAS 66155-69-9)
- 3-fluorocyclopentanesulfonyl chloride (CAS 1309433-76-8)
- 5-Chlorothiazolo[4,5-d]pyrimidin-7-amine (CAS 2090316-23-5)
- Neratinib Impurity 54 (CAS CATO-C4X-113454)
- Evocalcet Impurity 29 (CAS 1092366-92-1)
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- 3-Nitrobenzenesulfonamide (CAS 121-52-8)
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