Benazepril EP Impurity B(Mixture of Enantiomers) CAS 88372-39-8
| CAS No. | 88372-39-8 |
| Molecular Formula | 2*C24H28N2O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Benazepril EP Impurity B(Mixture of Enantiomers) (CAS 88372-39-8, C24H28N2O5HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C24H28N2O5HCl, Benazepril EP Impurity B(Mixture of Enantiomers) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 460.96 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | 2*C24H28N2O5 2*HCl |
| Molecular Weight | 460.96 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Benazepril Standards
- Benazepril Hydrochloride EP Impurity G Hydrochloride (CAS 103129-58-4)
- Benazepril Impurity 2 (CAS 105260-10-4)
- Benazepril EP Impurity F (CAS 109010-60-8)
- Benazepril tert-Butyl Ester (CAS 109010-61-9)
- Benazepril EP Impurity D (CAS 112110-48-2)
- Benazepril-d5 HCl (CAS 1279026-26-4)
- Benazepril-d5 (CAS 1279200-03-1)
- Benazepril EP Impurity A (CAS 131064-75-0)
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- 2,2-Difluoroethyl (2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptyl) carbonate (CAS 1980035-50-4)
- (2-(Isopropoxymethyl)phenyl)methanamine hydrochloride (CAS 28837-95-8)
- 3-(Aminomethyl)-4-cyclopropyl-1H-1,2,4-triazol-5(4H)-one Hydrochloride (CAS 1955540-90-5)
- N,N-Diphenyl-4-(phenylethynyl)aniline (CAS 96917-74-7)
- Peptide 440 (CAS CATO-CPTD788440)
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