Amitriptyline EP Impurity C CAS 894-71-3
| CAS No. | 894-71-3 |
| Molecular Formula | C19H21N |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Amitriptyline EP Impurity C meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Amitriptyline EP Impurity C (CAS 894-71-3, C19H21NHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C19H21NHCl, Amitriptyline EP Impurity C contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 299.84 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C19H21N HCl |
| Molecular Weight | 299.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Amitriptyline Standards
- Amitriptyline EP Impurity D (CAS 1159-03-1)
- Amitriptyline EP Impurity F (CAS 1159-82-6)
- Amitriptyline EP Impurity A (CAS 1210-35-1)
- Amitriptyline Hydrochloride - Impurity F (Oxalate Salt) (CAS 1246833-15-7)
- Amitriptyline-13C3 Hydrochloride (CAS 1329837-86-6)
- Amitriptyline-d6 Hydrochloride (CAS 203645-63-0)
- Amitriptyline EP Impurity C-d3 HCl (CAS 203784-52-5)
- Amitriptyline EP Impurity E HCl (Mixture of Diastereomers) (CAS 26360-49-6(free base))
Recommended Standards
- Nafamostat impurity 105 HCl (CAS CATO-C4X-1332105)
- Empagliflozin Impurity 312 (CAS CATO-C4X-1065312)
- Pioglitazone EP Impurity C (CAS 952188-00-0)
- (1S,3s)-3-(1-aminoethyl)cyclobutan-1-ol (CAS 1426523-55-8)
- 4-(Aminomethyl)-2-nitrophenol sulfate (CAS 2138204-41-6)
- Cytarabine Impurity 33 (CAS CATO-C4X-200533)
- Ethyl 2-amino-5-chloro-2,3-dihydro-1H-indene-2-carboxylate hydrochloride (CAS 1427501-68-5)
- 5-(Benzo[d][1,3]dioxol-5-yl)thiophene-2-carbaldehyde (CAS 887987-54-4)
- 2-azabicyclo[2.2.1]heptane hydrochloride (CAS 63838-50-6)
- Semaglutide impurity 59 (CAS CATO-C4X-222659)
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