Famotidine impurity 74 CAS 90224-97-8
| CAS No. | 90224-97-8 |
| Molecular Formula | C9H6ClNO |
| Molecular Weight | 179.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Famotidine impurity 74 (CAS 90224-97-8, C9H6ClNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C9H6ClNO, Famotidine impurity 74 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 179.60 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Famotidine impurity 74 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H6ClNO |
| Molecular Weight | 179.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Famotidine Standards
- Famotidine impurity 69 (CAS 850864-53-8)
- Famotidine Impurity 3 (CAS 13598-81-7)
- Famotidine impurity 75 (CAS 90924-16-6)
- Famotidine Impurity 45 (CAS 1644079-90-2)
- Famotidine Impurity 54 (CAS CATO-C4X-139254)
- Famotidine impurity 63 (CAS CATO-C4X-139263)
- Famotidine Impurity 78 (CAS 88068-99-9)
- Famotidine Impurity 79 (CAS CATO-C4X-139279)
Recommended Standards
- Isavuconazole Impurity 86 (CAS 40805-50-3)
- Ketoprofen Impurity 112 (CAS 42872-32-2)
- 89-64-5 438LQ62WNH 4-Chloro-2-nitrophenol Phenol, 4-chloro-2-nitro- AI3-28527 EINECS 201-927-5 2-Nitro-4-chlorophenol NSC 520345 UNII-438LQ62WNH (CAS 89-64-5)
- Hydroxychloroquine Impurity 10 (CAS 86-99-7)
- Ticagrelor Impurity 168 (CAS 1207276-00-3(free base))
- Pramipexole Impurity 44 (CAS 1001648-65-2)
- Lemborexant impurity 9 (CAS 1369763-94-9)
- Ethyl 6-methyl-2-oxo-4-(m-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 356773-71-2)
- N-(2-Methyl-1-phenyl-1-thioxopropan-2-yl)acetamide (CAS 89873-94-9)
- 3-(2-Bromo-5-chlorophenyl)propanoic acid (CAS 66192-05-0)
- ethyl 3,4,5-tribromopyrrole-2-carboxylate (CAS 740813-36-9)
- 6-(Pyridin-4-yloxy)pyridin-3-amine (CAS 1093952-87-4)
- (E)-3-(chloromethyl)-4-(4-methylbenzylidene)isoxazol-5(4H)-one (CAS 1142199-45-8)
- Endo-[Glu]31-Liraglutide (CAS CATO-C4X-199234)
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