Dasatinib Impurity 1 CAS 910297-61-9
| CAS No. | 910297-61-9 |
| Molecular Formula | C36H34Cl2N12O2S2 |
| Molecular Weight | 801.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Dasatinib Impurity 1 (CAS 910297-61-9, C36H34Cl2N12O2S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Dasatinib Impurity 1 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 801.77 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C36H34Cl2N12O2S2 |
| Molecular Weight | 801.77 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 25.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 12 |
| Sulfur Atoms | 2 |
Related Dasatinib Standards
- Dasatinib Impurity 75 (CAS CATO-C4X-160775)
- Dasatinib Impurity 16 (CAS 2468737-80-4)
- Dasatinib Impurity 33 (CAS CATO-C4X-160733)
- Dasatinib Impurity 37 (CAS 2468737-87-1)
- Dasatinib Impurity 5 (CAS 1159977-13-5)
- Dasatinib Carboxylic Acid Ethyl Ester (CAS 910297-62-0)
- Dasatinib Impurity 6 (CAS CATO-C4X-16076)
- Dasatinib Impurity 64 (CAS 2468737-75-7)
Recommended Standards
- Sitafloxacin impurity 48 (CAS CATO-C4X-111548)
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- Ketoprofen Impurity 27 (CAS 2716236-51-8)
- Aztreonam Impurity 39 (CAS CATO-C4X-152239)
- Lamotrigine EP Impurity E (CAS 50-45-3)
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- 2-(2-Thienyl)benzaldehyde (CAS 99902-07-5)
- (1R,2S,4R)-2-Amino-4-methylcyclopentanecarboxylic acid (CAS 787545-59-9)
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- 6-Methoxyisoquinolin-5-amine (CAS 72677-90-8)
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