Megestrol Acetate EP Impurity E CAS 982-89-8
| CAS No. | 982-89-8 |
| Molecular Formula | C24H30O4 |
| Molecular Weight | 382.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Megestrol Acetate EP Impurity E is closely related to a flavonoid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Megestrol Acetate EP Impurity E (CAS 982-89-8), a pharmacopoeial impurity reference standard (molecular formula C24H30O4, MW 382.49 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Megestrol Acetate EP Impurity E (C24H30O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Megestrol Acetate EP Impurity E under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C24H30O4 |
| Molecular Weight | 382.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Megestrol Standards
- Megestrol Acetate EP Impurity C (CAS 74910-22-8)
- Megestrol Acetate EP Impurity D (CAS 32634-95-0)
- Megestrol-17-Acetate (CAS 595-33-5)
- Megestrol acetate (CAS 51154-23-5)
- Megestrol Acetate EP Impurity J (CAS 14994-27-5)
- Megestrol Acetate-d3 (CAS 162462-72-8)
- Megestrol Acetate EP Impurity I (CAS CATO-C4X-14149)
- Megestrol acetate EP Impurity G (CAS 1259198-59-8)
Recommended Standards
- Enalapril Impurity 39 (CAS 2055735-10-7)
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- Norethisterone Acetate EP Impurity D (CAS CATO-C4X-171316)
- Montelukast Impurity 34 (CAS 162515-68-6)
- Orforglipron Impurity 43 (CAS 2025595-61-1(free base))
- Bupropion Impurity 43 (CAS CATO-C4X-120343)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com