Apremilast Impurity 59 CAS CATO-C4X-100959
| CAS No. | CATO-C4X-100959 |
| Molecular Formula | C42H42N4O12S |
| Molecular Weight | 826.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Apremilast Impurity 59 (C42H42N4O12S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 24.0, corresponding to approximately 24 ring(s) or double-bond equivalent(s). With a molecular weight of 826.87 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Apremilast Impurity 59 (CAS CATO-C4X-100959, C42H42N4O12S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C42H42N4O12S |
| Molecular Weight | 826.87 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 24.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Apremilast Standards
- Apremilast Impurity 46 (CAS CATO-C4X-100946)
- Apremilast Impurity 65 (CAS 2487573-08-8)
- Apremilast Impurity 3 (CAS 1802246-60-1)
- Apremilast Impurity 124 (CAS 2741194-01-2)
- Apremilast Impurity 24 (CAS 2487573-01-1)
- Apremilast Impurity 53 (CAS CATO-C4X-100953)
- Apremilast Impurity 6 (CAS 1809170-71-5)
- Apremilast Impurity 7 (CAS 2096492-41-8)
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