Crizotinib Impurity 66 CAS CATO-C4X-102566
| CAS No. | CATO-C4X-102566 |
| Molecular Formula | C9H9Cl2FO |
| Molecular Weight | 223.07 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C9H9Cl2FO, Crizotinib Impurity 66 contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 223.07 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Crizotinib Impurity 66 (CAS CATO-C4X-102566, C9H9Cl2FO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Crizotinib Impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H9Cl2FO |
| Molecular Weight | 223.07 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
Related Crizotinib Standards
- Crizotinib impurity 16 (CAS 877397-65-4)
- Crizotinib Impurity 5 (CAS 330156-50-8)
- Crizotinib Impurity 67 (CAS CATO-C4X-102567)
- Crizotinib impurity 11 (CAS 1269429-29-9)
- Crizotinib impurity 22 (CAS 3469-69-0)
- Crizotinib Impurity 68 (CAS CATO-C4X-102568)
- Crizotinib impurity 18 (CAS 2322921-92-4)
- Crizotinib Impurity 69 (CAS CATO-C4X-102569)
Recommended Standards
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- Meropenem Impurity 10 (CAS 1562123-84-5)
- Ceftibuten Impurity 8 (CAS 97519-40-9)
- Procaine Impurity 15 HCl (CAS CATO-C4X-262315)
- Rodatristat (CAS 1673568-73-4)
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- 5-Bromo-2-oxoindoline-7-carboxylic acid (CAS 1225692-82-9)
- N-Methylpiperidin-4-amine hydrochloride (CAS 1416373-43-7)
- 1,1,1-Trifluoro-3-(3-fluorophenyl)propan-2-amine (CAS 1599349-68-4)
- 2'-Methyl-[1,1'-biphenyl]-2-amine hydrochloride (CAS 1203-42-5)
- Bonemarrow-Derived Mesenchymal Stem Cells Affinity Peptide trifluoroacetate salt (CAS 683750-83-6)
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