Crizotinib impurity 11 CAS 1269429-29-9
| CAS No. | 1269429-29-9 |
| Molecular Formula | C13H21N3O2 |
| Molecular Weight | 251.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Crizotinib impurity 11 (CAS 1269429-29-9) is a certified pharmaceutical impurity reference standard with the molecular formula C13H21N3O2 and a molecular weight of 251.32 g/mol.
Based on its molecular formula C13H21N3O2, Crizotinib impurity 11 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 251.32 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H21N3O2 |
| Molecular Weight | 251.32 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 3 |
Related Crizotinib Standards
- Crizotinib impurity 18 (CAS 2322921-92-4)
- Crizotinib Impurity 69 (CAS CATO-C4X-102569)
- Crizotinib Impurity 71 (CAS CATO-C4X-102571)
- Crizotinib impurity 15 (CAS 1175708-03-8)
- Crizotinib impurity 24 (CAS 141699-59-4)
- Crizotinib Impurity 66 (CAS CATO-C4X-102566)
- Crizotinib impurity 33 (CAS CATO-C4X-102533)
- Crizotinib impurity 16 (CAS 877397-65-4)
Recommended Standards
- 81154-16-7 (5E)-2-Mercapto-5-(4-methoxybenzylidene)-1,3-thiazol-4(5H)-one MFCD04969032 (CAS 81154-16-7)
- Oxcarbazepine EP Impurity G (CAS 15882-79-8)
- 81154-02-1 (5E)-5-[(3-Methoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one DTXSID60364357 (CAS 81154-02-1)
- Sunitinib Impurity 36 (CAS CATO-C4X-133336)
- Montelukast Impurity 19 (CAS 1258428-71-5)
- Cefmetazole Impurity 31 (CAS 55862-52-7)
- Cefoxitin EP Impurity B (CAS CATO-C4X-15782)
- 1198604-53-3 3-Benzyl-3-azabicyclo[3.1.0]hexan-2-one 3440AA C12H13NO (CAS 1198604-53-3)
- 1-(((4-Nitrophenoxy)carbonyl)oxy)ethyl isobutyrate, 97% (CAS 194995-47-6)
- (1-tert-Butylvinyloxy)trimethylsilane (CAS 17510-46-2)
- 6-Methoxy-1H-indole-5-carbonitrile (CAS 1423120-43-7)
- 2-Phenyl-5-vinyl-1,3,4-oxadiazole (CAS 864085-48-3)
- 3-Ethyl-7-fluoro-3-methyl-3,4-dihydro-2H-[1,3'-biquinolin]-2-one (CAS 918646-06-7)
- Tirzepatide Impurity 58 (CAS CATO-C4X-324058)
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