Crizotinib impurity 16 CAS 877397-65-4
| CAS No. | 877397-65-4 |
| Molecular Formula | C8H7Cl2FO |
| Molecular Weight | 209.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Crizotinib impurity 16 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Crizotinib impurity 16 (CAS 877397-65-4), a pharmacopoeial impurity reference standard (molecular formula C8H7Cl2FO, MW 209.04 g/mol) used for the identification and quantification of trace impurities in APIs.
Crizotinib impurity 16 (C8H7Cl2FO) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H7Cl2FO |
| Molecular Weight | 209.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
Related Crizotinib Standards
- Crizotinib Impurity 5 (CAS 330156-50-8)
- Crizotinib Impurity 67 (CAS CATO-C4X-102567)
- Crizotinib Impurity 66 (CAS CATO-C4X-102566)
- Crizotinib impurity 22 (CAS 3469-69-0)
- Crizotinib Impurity 68 (CAS CATO-C4X-102568)
- Crizotinib impurity 19 (CAS CATO-C4X-102519)
- Crizotinib Impurity 70 (CAS CATO-C4X-102570)
- Crizotinib Impurity 73 (CAS CATO-C4X-102573)
Recommended Standards
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Why CATO?
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