Ceritinib Impurity 22 CAS CATO-C4X-104822
| CAS No. | CATO-C4X-104822 |
| Molecular Formula | C13H13Cl2N3S |
| Molecular Weight | 314.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution, Ceritinib Impurity 22 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 314.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Ceritinib Impurity 22 (CAS CATO-C4X-104822, C13H13Cl2N3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ceritinib Impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H13Cl2N3S |
| Molecular Weight | 314.23 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Ceritinib Standards
- Ceritinib Impurity 16 (CAS CATO-C4X-104816)
- Ceritinib Impurity 23 (CAS CATO-C4X-104823)
- Ceritinib Impurity 24 (CAS CATO-C4X-104824)
- Ceritinib Impurity 18 (CAS CATO-C4X-1048918)
- Ceritinib Impurity 82 (CAS CATO-C4X-104882)
- Ceritinib Impurity 17 (CAS CATO-C4X-104817)
- Ceritinib Impurity 1 (CAS CATO-C4X-10481)
- Ceritinib Impurity 83 (CAS CATO-C4X-104883)
Recommended Standards
- N-(3,5-Bis(trifluoromethyl)phenyl)(propylamino)formamide (CAS 23751-81-7)
- N-(2,4-dichlorophenyl)-1-(2-(ethylthio)-1-methyl-1H-imidazol-5-yl)methanimine (CAS 320423-10-7)
- 2-Bromo-1-(3,4-dihydro-2h-1,4-benzothiazin-4-yl)-3-methylbutan-1-one (CAS 1097794-82-5)
- 8-Hydroxy-5,7-dinitronaphthalene-2-sulfonic acid (CAS 483-84-1)
- Finasteride Impurity 62 (CAS CATO-C4X-164562)
- Tenofovir disoproxil Impurity 90 (CAS 3084-40-0)
- Olmesartan Impurity 34 (CAS 116857-04-6)
- 4-(4-Bromophenyl)-2-methylpyrimidine (CAS 499785-50-1)
- 5-Cyclopropoxy-2-isopropylnicotinonitrile (CAS 1243322-91-9)
- Methyl 2-(isopropylamino)-4-(1h-1,2,4-triazol-1-yl)butanoate (CAS 1339881-73-0)
- 1-(Pyridin-4-yl)cyclobutan-1-amine dihydrobromide (CAS 1211593-50-8)
- 2-(Benzyloxy)-5-chloropyrazine (CAS 1308649-66-2)
- 1-((4-Bromonaphthalen-1-yl)sulfonyl)-4-methylpiperazine (CAS 312525-99-8)
- Palmitoyl Tripeptide -5 · 2 TFA (CAS 623172-56-5)
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