Sofosbuvir Impurity 28 CAS CATO-C4X-105228
| CAS No. | CATO-C4X-105228 |
| Molecular Formula | C22H29FN3O9P |
| Molecular Weight | 529.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Sofosbuvir Impurity 28 is closely related to a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Sofosbuvir Impurity 28 (CAS CATO-C4X-105228, C22H29FN3O9P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Sofosbuvir Impurity 28 (C22H29FN3O9P) contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H29FN3O9P |
| Molecular Weight | 529.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Sofosbuvir Standards
- Sofosbuvir (CAS 1190307-88-0)
- Sofosbuvir Impurity 22 (CAS 1190308-01-0)
- Sofosbuvir Impurity 23 (CAS CATO-C4X-105223)
- Sofosbuvir Impurity 24 (CAS CATO-C4X-105224)
- Sofosbuvir Impurity 25 (CAS CATO-C4X-105225)
- Sofosbuvir Impurity 26 (CAS CATO-C4X-105226)
- Sofosbuvir Impurity 27 (CAS CATO-C4X-105227)
- Sofosbuvir Impurity 29 (CAS CATO-C4X-105229)
Recommended Standards
- Sofosbuvir Impurity 30 (CAS CATO-C4X-105230)
- Sofosbuvir Impurity 31 (CAS CATO-C4X-105231)
- Sofosbuvir Impurity 33 (CAS CATO-C4X-105233)
- (S)-(((2R,3S,4R,5R)-L-Sofosbuvir Isomer (CAS CATO-C4X-105235)
- Clofazimine EP Impurity A (CAS 102262-55-5)
- Trimetazidine Impurity 13 (CAS 92700-82-8)
- Montelukast Impurity 48 (CAS 87764-54-3)
- Brivaracetam Impurity 128 (CAS CATO-C4X-2007128)
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