Sofosbuvir Impurity 89 CAS CATO-C4X-105289
| CAS No. | CATO-C4X-105289 |
| Molecular Formula | C16H18FN2O8P |
| Molecular Weight | 416.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Sofosbuvir Impurity 89 (CAS CATO-C4X-105289, C16H18FN2O8P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Sofosbuvir Impurity 89 (C16H18FN2O8P) contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Sofosbuvir Impurity 89 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H18FN2O8P |
| Molecular Weight | 416.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Sofosbuvir Standards
- Sofosbuvir Impurity 51 (CAS 1233335-78-8)
- Sofosbuvir Impurity 97 (CAS 1911578-88-5)
- Sofosbuvir Impurity 95 (CAS CATO-C4X-105295)
- Sofosbuvir Impurity 96 (CAS 1392015-05-2)
- Sofosbuvir Impurity 85 (CAS 1621160-31-3)
- Sofosbuvir Impurity 68 (CAS 1496551-65-5)
- Sofosbuvir Impurity N40 (CAS 1256490-52-4)
- Sofosbuvir Impurity 120 (CAS 2190510-88-2)
Recommended Standards
- 898757-17-0 5-(5,5-Dimethyl-1,3-dioxan-2-yl)-1-(3-iodo-4-methylphenyl)pentan-1-one DTXSID60646069 (CAS 898757-17-0)
- Alectinib Impurity 10 (CAS 1256584-74-3)
- Sulfo-MBS (sodium) (CAS 92921-25-0)
- (1S,2R,1'S)-Cypermethrin (CAS 83860-31-5)
- Rapamycin Impurity 8 (CAS CATO-C4X-17468)
- Rosuvastatin Impurity 143 (CAS CATO-C4X-1169143)
- Tenofovir alafenamide Impurity 17 (CAS 382140-25-2(Free Base))
- 1,2-Benzenediamine-d8 (CAS 1219798-78-3)
- Ethyl 3-oxo-(3-pyrimidin-2-yl)propanoate (CAS 1093114-80-7)
- 2-Methanesulfonyl-2-methylpropanoyl chloride (CAS 1017540-45-2)
- 2-chloro-N-(2-oxoazepan-3-yl)acetamide (CAS 152266-99-4)
- Methyl 4-chloro-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxylate (CAS 947665-29-4)
- Vortioxetine Impurity 46 (CAS 1253056-29-9)
- Des-Lys20(Side Chain)-Semaglutide (CAS CATO-C4X-2226280)
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