Ibrutinib Impurity 131 CAS CATO-C4X-1064131
| CAS No. | CATO-C4X-1064131 |
| Molecular Formula | C24H26N6O3 |
| Molecular Weight | 446.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 446.50 g/mol gives Ibrutinib Impurity 131 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Ibrutinib Impurity 131 (CAS CATO-C4X-1064131) is a certified pharmaceutical impurity reference standard with the molecular formula C24H26N6O3 and a molecular weight of 446.50 g/mol.
Ibrutinib Impurity 131 (C24H26N6O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H26N6O3 |
| Molecular Weight | 446.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Ibrutinib Standards
- Ibrutinib Impurity 132 (CAS CATO-C4X-1064132)
- Ibrutinib-d5 (CAS 1553977-17-5)
- Ibrutinib Impurity 2 (CAS 1839099-22-7)
- Ibrutinib Impurity 8 (CAS CATO-C4X-10648)
- Ibrutinib Impurity 170 (CAS CATO-C4X-1064170)
- Ibrutinib Impurity 78 (CAS 2031255-24-8)
- Ibrutinib Racemate (CAS 936563-87-0)
- Ibrutinib (CAS 936563-96-1)
Recommended Standards
- Mitoxantrone Impurity 13 (CAS 70476-74-3)
- N-(3-Methyl-6-nitrobenzo[d]thiazol-2(3H)-ylidene)-4-(pyrrolidin-1-ylsulfonyl)benzamide (CAS 850910-42-8)
- Olmesartan Medoxomilum EP Impurity A (CAS 144689-24-7)
- di-tert-butyl((2S,3S)-3-(tert-butyl)-4-phenoxy-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl)phosphine oxide (CAS 2374143-31-2)
- Azathioprine Impurity N4 (CAS 5167-18-0)
- Sildenafil Impurity N1 (CAS 911715-34-9)
- Benidipine Impurity 56 (CAS CATO-C4X-112056)
- Tetrahydrothiophen-3-one (CAS 1003-04-9)
- Tetrachlorocatechol (CAS 1198-55-6)
- (3AS,9bR)-6-(trifluoromethyl)-1,2,3,3a,4,9b-hexahydro-5H-pyrrolo[3,4-c]isoquinolin-5-one (CAS 873915-29-8)
- (3H-imidazo[4,5-c]pyridin-2-yl)methanol (CAS 92381-62-9)
- 3-[(2,2,2-trifluoroethoxy)methyl]benzoic acid (CAS 438475-19-5)
- Polyoxyethylene Tridecyl Ether (CAS 78330-21-9)
- Liraglutide-d8 Tritrifluoroacetate (CAS CATO-C4X-199223)
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