Ibrutinib Impurity 31 CAS CATO-C4X-106431
| CAS No. | CATO-C4X-106431 |
| Molecular Formula | C25H25ClN6O2 |
| Molecular Weight | 476.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ibrutinib Impurity 31 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Ibrutinib Impurity 31 (CAS CATO-C4X-106431) is a certified pharmaceutical impurity reference standard with the molecular formula C25H25ClN6O2 and a molecular weight of 476.96 g/mol.
The molecular framework of Ibrutinib Impurity 31 (C25H25ClN6O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Ibrutinib Impurity 31 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C25H25ClN6O2 |
| Molecular Weight | 476.96 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Ibrutinib Standards
- Ibrutinib Impurity 3 (CAS 1288338-96-4)
- Ibrutinib Impurity 92 (CAS CATO-C4X-106492)
- Ibrutinib Impurity 93 (CAS CATO-C4X-106493)
- Ibrutinib Impurity 13 (Mixture of Diastereomers) (CAS 1654820-87-7)
- Ibrutinib Impurity 137 (CAS CATO-C4X-1064137)
- Ibrutinib Impurity 160 (CAS CATO-C4X-1064160)
- Ibrutinib Impurity 169 (CAS CATO-C4X-1064169)
- Ibrutinib Impurity 44 (CAS 2031255-26-0)
Recommended Standards
- Methyl 5-((3-chlorophenyl)carbamoyl)-2-((5,6-dimethyl-2H-pyran-2-yl)(ethoxy)amino)-4-methylthiophene-3-carboxylate (CAS 505096-40-2)
- tert-Butyl 4-[6-(4-chlorophenyl)-5-cyano-2-(pyridin-4-yl)pyrimidin-4-yl]piperazine-1-carboxylate (CAS 383148-76-3)
- 3,5-Dibromo-2,6-difluoro-N-(4-nitro-2-(trifluoromethyl)phenyl)pyridin-4-amine (CAS 37729-25-2)
- (E)-N'-((3-([1,1'-biphenyl]-4-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)-4-chlorobenzohydrazide (CAS 956211-82-8)
- Rotigotine impurity 01 (CAS 87172-82-5)
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- Cefmetazole Impurity 22 (CAS CATO-C4X-150722)
- (4-Bromo-3-fluoro-2-methylphenyl)methanol (CAS 2012740-55-3)
- (3R,4R)-1-benzyl-3,4-difluoropyrrolidine (CAS 2055174-55-3)
- N-(2-(3,4-Dihydroxyphenyl)-2-oxoethyl)acetamide (CAS 14522-07-7)
- 2,4-Dihydroxy-6-pentylbenzoic Acid (CAS 491-72-5)
- N1,N4-Dibenzylidenebenzene-1,4-diamine (CAS 797-20-6)
- 2-Bromo-6-(2,2,2-trifluoroethoxy)pyridine (CAS 869640-44-8)
- 263251-78-1 NMG938VJ6T D-3 Tavilermide [USAN:INN] UNII-NMG938VJ6T MIM-D3 MIM-D 3 D 3 (peptide) Tavilermide (CAS 263251-78-1)
Why CATO?
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