Empagliflozin impurity 187 CAS CATO-C4X-1065187
| CAS No. | CATO-C4X-1065187 |
| Molecular Formula | C24H29ClO8 |
| Molecular Weight | 480.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Empagliflozin impurity 187.
CATO supplies Empagliflozin impurity 187 (CAS CATO-C4X-1065187), a pharmacopoeial impurity reference standard (molecular formula C24H29ClO8, MW 480.94 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Empagliflozin impurity 187 (C24H29ClO8) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H29ClO8 |
| Molecular Weight | 480.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 140 (CAS 2781890-39-7)
- Empagliflozin Impurity 161 (CAS 1620758-25-9/1620758-26-0)
- Empagliflozin Impurity 168 (CAS CATO-C4X-1065168)
- Empagliflozin Impurity 18 (CAS 1279691-36-9)
- Empagliflozin Impurity 19 (CAS CATO-C4X-106519)
- Empagliflozin Impurity 313 (CAS 1620758-25-9)
- Empagliflozin Impurity 48 (CAS 915095-96-4)
- Empagliflozin Impurity 151 (CAS CATO-C4X-1065151)
Recommended Standards
- Tolvaptan Impurity 7 (CAS 1346599-75-4)
- VRT 043198 (CAS 244133-31-1)
- Bexagliflozin Impurity 8 (CAS CATO-C4X-33228)
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