Empagliflozin Impurity 18 CAS 1279691-36-9
| CAS No. | 1279691-36-9 |
| Molecular Formula | C24H29ClO8 |
| Molecular Weight | 480.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Empagliflozin Impurity 18 (CAS 1279691-36-9, C24H29ClO8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C24H29ClO8, Empagliflozin Impurity 18 contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 480.94 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H29ClO8 |
| Molecular Weight | 480.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 140 (CAS 2781890-39-7)
- Empagliflozin Impurity 161 (CAS 1620758-25-9/1620758-26-0)
- Empagliflozin Impurity 168 (CAS CATO-C4X-1065168)
- Empagliflozin impurity 187 (CAS CATO-C4X-1065187)
- Empagliflozin Impurity 19 (CAS CATO-C4X-106519)
- Empagliflozin Impurity 313 (CAS 1620758-25-9)
- Empagliflozin Impurity 48 (CAS 915095-96-4)
- Empagliflozin Impurity 151 (CAS CATO-C4X-1065151)
Recommended Standards
- VRT 043198 (CAS 244133-31-1)
- N-(4-Chlorobenzyl)-N-(4-nitrophenyl)-2-((3-(pyridin-3-yl)-1H-1,2,4-triazol-5-yl)thio)acetamide (CAS 337488-65-0)
- Tolvaptan Impurity 7 (CAS 1346599-75-4)
- 4-(4-Chlorophenyl)-2-[(4-methylphenyl)sulfanyl]-6-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile (CAS 303984-65-8)
- Resmetirom impurity 77 (CAS CATO-C4X-291277)
- Apalutamide Impurity 25 (CAS CATO-C4X-274925)
- Ibuprofen Impurity 75 (CAS 51407-46-6)
- Mosapride Impurity 7 (CAS 152013-26-8)
- Cyclohexanecarboxaldehyde (CAS 2043-61-0)
- Methyl (E)-2-cyano-3-(naphthalen-2-yl)acrylate (CAS 60239-42-1)
- 2-(4-Chloro-2-methylphenoxy)-4-(dimethylamino)pyridine-3-carbonitrile (CAS 341967-14-4)
- 937619-34-6 3-[(5-Bromo-2-fluorophenyl)methyl]azetidine DTXSID20588370 (CAS 937619-34-6)
- N-(4-methoxybenzyl)-2-((4-phenyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 502553-59-5)
- Semaglutide (CAS 910463-68-2)
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