Empagliflozin impurity 251 CAS CATO-C4X-1065251
| CAS No. | CATO-C4X-1065251 |
| Molecular Formula | C14H9ClFIO |
| Molecular Weight | 374.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Empagliflozin impurity 251 (CAS CATO-C4X-1065251, C14H9ClFIO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a hydroxyl group, an ether linkage, fluorine/chlorine/iodine substitution, a polycyclic aromatic system, Empagliflozin impurity 251 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 374.58 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C14H9ClFIO |
| Molecular Weight | 374.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl/I-containing |
Related Empagliflozin Standards
- Empagliflozin impurity 242 (CAS CATO-C4X-1065242)
- Empagliflozin impurity 246 (CAS CATO-C4X-1065246)
- Empagliflozin Impurity 80 (CAS CATO-C4X-106580)
- Empagliflozin Impurity 81 (CAS CATO-C4X-106581)
- Empagliflozin Impurity 305 (CAS CATO-C4X-1065305)
- Empagliflozin Impurity 102 (CAS CATO-C4X-1065102)
- Empagliflozin impurity 208 (CAS CATO-C4X-1065208)
- Empagliflozin Impurity 146 (CAS CATO-C4X-1065146)
Recommended Standards
- tert-Butyl (3-bromo-5-chloro-4-(trifluoromethyl)phenyl)carbamate (CAS 2803281-61-8)
- N,N,N',N'-tetraethyl-1,1-bis(phenylethynyl)silanediamine (CAS 189632-30-2)
- Bis(2-ethylhexyl) 2,2'-thiodiacetate (CAS 24293-43-4)
- tert-Butyl (R)-3-((2-((tert-butyldimethylsilyl)oxy)ethoxy)methyl)piperazine-1-carboxylate (CAS 2798809-28-4)
- Bendamustine Impurity 14 (CAS CATO-C4X-127114)
- Topiroxostat Impurity 68 (CAS CATO-C4X-105568)
- Cholecalciferol EP Impurity B (CAS 434-16-2)
- 3-(2-Chlorophenyl)-N-(furan-2-ylmethyl)-5-methylisoxazole-4-carboxamide (CAS 301227-23-6)
- Digoxin EP Impurity G (CAS 55576-67-5)
- 5-Cyclopropylpyridine-3-carboxylic acid (CAS 893738-23-3)
- 4-(Difluoromethyl)-6-iodo-5-nitropicolinaldehyde (CAS 1805193-68-3)
- 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-[(6-O-beta-D-galactopyranosyl-beta-D-glucopyranosyl)oxy]-5,7-dihydroxy- (CAS 878806-08-7)
- 2-(3,5-Difluoro-4-nitrophenyl)acetic acid (CAS 932373-91-6)
- Semaglutide Impurity 176 (CAS CATO-C4X-2226176)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com