Empagliflozin impurity 246 CAS CATO-C4X-1065246
| CAS No. | CATO-C4X-1065246 |
| Molecular Formula | C14H9ClFIO |
| Molecular Weight | 374.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Empagliflozin impurity 246.
As a process- or degradation-related impurity, Empagliflozin impurity 246 (CAS CATO-C4X-1065246, C14H9ClFIO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Empagliflozin impurity 246 (C14H9ClFIO) contains a hydroxyl group, an ether linkage, fluorine/chlorine/iodine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H9ClFIO |
| Molecular Weight | 374.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl/I-containing |
Related Empagliflozin Standards
- Empagliflozin impurity 242 (CAS CATO-C4X-1065242)
- Empagliflozin impurity 251 (CAS CATO-C4X-1065251)
- Empagliflozin Impurity 80 (CAS CATO-C4X-106580)
- Empagliflozin Impurity 81 (CAS CATO-C4X-106581)
- Empagliflozin Impurity 305 (CAS CATO-C4X-1065305)
- Empagliflozin Impurity 102 (CAS CATO-C4X-1065102)
- Empagliflozin impurity 208 (CAS CATO-C4X-1065208)
- Empagliflozin Impurity 146 (CAS CATO-C4X-1065146)
Recommended Standards
- tert-Butyl (3-bromo-5-chloro-4-(trifluoromethyl)phenyl)carbamate (CAS 2803281-61-8)
- Bis(2-ethylhexyl) 2,2'-thiodiacetate (CAS 24293-43-4)
- 4-(4-methoxyphenyl)-5-sulfanyl-8,10-dithia-4,6-diazatricyclo[7.4.0.0²,⁷]trideca-1(9),2(7),5-trien-3-one (CAS 793716-05-9)
- N,N,N',N'-tetraethyl-1,1-bis(phenylethynyl)silanediamine (CAS 189632-30-2)
- Amlodipine Impurity 132 (CAS CATO-C4X-1095132)
- Cloransulam-Methyl Impurity 2 (CAS CATO-C4X-31702)
- Osimertinib Impurity 46 (CAS CATO-C4X-204546)
- n-(1-Hydroxypropan-2-yl)-2-(thiophen-2-yl)thiazole-4-carboxamide (CAS 1089535-46-5)
- 3-Cyclopropoxy-5-methoxybenzenesulfonamide (CAS 1243406-84-9)
- 2-Amino-N-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide (CAS 38201-62-6)
- 1-(6-Amino-2,3-dichlorophenyl)-2,2,2-trifluoroethan-1-one (CAS 277301-96-9)
- Ethyl 1-(3,5-dimethylphenyl)-1H-1,2,4-triazole-3-carboxylate (CAS 1245643-93-9)
- N-(2-Chloro-6-methylphenyl)-3-(pyrrolidin-1-yl)butanamide hydrochloride (CAS 77985-19-4)
- [y-Glu15]-Semaglutide Impurity 134 (CAS CATO-C4X-2226134)
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