Empagliflozin Impurity 46 CAS CATO-C4X-106546
| CAS No. | CATO-C4X-106546 |
| Molecular Formula | C17H17ClO3 |
| Molecular Weight | 304.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Empagliflozin Impurity 46 (CAS CATO-C4X-106546, C17H17ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Empagliflozin Impurity 46 (C17H17ClO3) is characterized by a steroid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H17ClO3 |
| Molecular Weight | 304.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 4 (CAS 2770456-61-4)
- Empagliflozin Impurity 310 (CAS CATO-C4X-1065310)
- Empagliflozin Impurity 154 (CAS 2452301-22-1)
- Empagliflozin Impurity 281 (CAS 1096342-71-0)
- Empagliflozin Impurity 284 (CAS 1711323-05-5)
- Empagliflozin impurity 56 (CAS 1628918-33-1)
- Empagliflozin impurity 260 (CAS CATO-C4X-1065260)
- Empagliflozin Impurity 130 (CAS 289039-54-9)
Recommended Standards
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