Tofacitinib Impurity 138 CAS CATO-C4X-1079138
| CAS No. | CATO-C4X-1079138 |
| Molecular Formula | C19H22ClN5 |
| Molecular Weight | 355.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Tofacitinib Impurity 138 (CAS CATO-C4X-1079138), a pharmacopoeial impurity reference standard (molecular formula C19H22ClN5, MW 355.86 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Tofacitinib Impurity 138 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 355.86 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H22ClN5 |
| Molecular Weight | 355.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Impurity 85 (CAS CATO-C4X-107985)
- Tofacitinib Impurity 150 (CAS 1616761-01-3)
- Tofacitinib Impurity 84 (CAS 1675248-18-6)
- Tofacitinib Impurity 132 (CAS CATO-C4X-1079132)
- Tofacitinib Impurity 112 (CAS CATO-C4X-1079112)
- Tofacitinib Impurity 51 (CAS 2504210-38-0)
- Tofacitinib Impurity 234 (CAS CATO-C4X-1079234)
- Tofacitinib Impurity 202 (CAS CATO-C4X-1079202)
Recommended Standards
- N-(4-chlorophenyl)-4-(3-phenylallyl)piperazine-1-carboxamide (CAS 401636-59-7)
- Haloperidol Impurity 20 (CAS 185626-66-8)
- Ethyl 4-chloro-2-(((2-cyanoethyl)thio)methyl)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate (CAS 885460-57-1)
- Amodiaquine Impurity 11 (CAS CATO-C4X-247111)
- Atrasentan Impurity 181 (CAS 1073590-82-5)
- Propofol Impurity 47 (CAS CATO-C4X-147347)
- Indocyanine Green Impurity 32 (CAS CATO-C4X-250332)
- 898785-26-7 6-Chloro-1-(3-methylphenyl)hexan-1-one DTXSID00642368 (CAS 898785-26-7)
- (2R)-1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)pyrrolidine-2-carboxylic acid (CAS 1212074-78-6)
- Triptorelin Impurity 27 (CAS CATO-C4X-186227)
- (4-((Diethylamino)methyl)phenyl)methanol (CAS 91271-57-7)
- 2-Methoxy-3-methylbenzyl chloride (CAS 82212-51-9)
- 1-(2-Chloroethyl)-3-methylurea (CAS 74378-14-6)
- MOTS-c Peptide (CAS 1627580-64-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com