Haloperidol Impurity 20 CAS 185626-66-8
| CAS No. | 185626-66-8 |
| Molecular Formula | C21H22ClNO2 |
| Molecular Weight | 355.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Haloperidol Impurity 20 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Haloperidol Impurity 20 (CAS 185626-66-8) is a certified pharmaceutical impurity reference standard with the molecular formula C21H22ClNO2 and a molecular weight of 355.86 g/mol.
The molecular framework of Haloperidol Impurity 20 (C21H22ClNO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H22ClNO2 |
| Molecular Weight | 355.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2010 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Haloperidol Standards
- Haloperidol pyridinium Chloride Impurity (CAS 125785-69-5)
- Haloperidol Impurity 39 (CAS 52669-92-8)
- Haloperidol Impurity 22 (CAS 660844-75-7)
- Haloperidol EP Impurity A (CAS 3109-12-4)
- Haloperidol EP Impurity B (CAS 1391052-53-1)
- Haloperidol (CAS 52-86-8)
- Haloperidol Impurity 15 (CAS CATO-C4X-146115)
- Haloperidol-d4 (CAS 1189986-59-1)
Recommended Standards
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