Tofacitinib Impurity 169 DiHCl CAS CATO-C4X-1079169
| CAS No. | CATO-C4X-1079169 |
| Molecular Formula | C16H25N5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Tofacitinib Impurity 169 DiHCl (CAS CATO-C4X-1079169) is a certified pharmaceutical impurity reference standard with the molecular formula C16H25N5HCl and a molecular weight of 323.87 g/mol.
Tofacitinib Impurity 169 DiHCl (C16H25N5HCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C16H25N5 2*HCl |
| Molecular Weight | 323.87 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 123 DiHCl (CAS 1062580-52-2)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
- Tofacitinib Impurity 3 (CAS 1092578-47-6)
Recommended Standards
- Pregabalin Impurity 128 (CAS CATO-C4X-1312128)
- Rocuronium Impurity 75 (CAS CATO-C4X-124275)
- Tafamidis Impurity 3 (CAS 1183404-30-9)
- 2-Amino-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(1H)-one (CAS 81766-02-1)
- 1-(5-Methoxypyridin-2-yl)cyclopropanamine dihydrochloride (CAS 1384264-66-7)
- 1-(4-(Methoxymethyl)phenyl)butan-1-one (CAS 792154-29-1)
- Methyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate (CAS 127717-18-4)
- 2-{[(pyridin-3-ylmethyl)carbamoyl]methoxy}acetic acid (CAS 312924-82-6)
- 6-Neopentylpyrimidin-4-amine (CAS 1248638-14-3)
- Ac, Gastrin Releasing Peptide (20-27), porcine (CAS 77714-20-6)
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