Tofacitinib Impurity 73 CAS CATO-C4X-107973
| CAS No. | CATO-C4X-107973 |
| Molecular Formula | C16H22N6O2 |
| Molecular Weight | 330.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Tofacitinib Impurity 73 (CAS CATO-C4X-107973) is a certified pharmaceutical impurity reference standard with the molecular formula C16H22N6O2 and a molecular weight of 330.38 g/mol.
Based on its molecular formula C16H22N6O2, Tofacitinib Impurity 73 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 330.38 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H22N6O2 |
| Molecular Weight | 330.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Tofacitinib Standards
- Tofacitinib Impurity 17 (CAS 1675248-19-7)
- Tofacitinib Impurity 120 (CAS CATO-C4X-1079120)
- Tofacitinib Impurity 16 (CAS 2328165-36-0)
- Tofacitinib Impurity 47 (CAS CATO-C4X-107947)
- Tofacitinib Impurity 119 (CAS 2407039-29-4)
- Tofacitinib Impurity 139 (CAS CATO-C4X-1079139)
- Tofacitinib Impurity 159 (CAS 1640971-51-2)
- Tofacitinib Impurity 171 (CAS CATO-C4X-1079171)
Recommended Standards
- N-Nitroso Tofacitinib Impurity 185 (CAS CATO-C4X-1079185)
- Sildenafil Impurity 11 (CAS 139756-03-9)
- Sildenafil Impurity 96 (CAS CATO-C4X-112896)
- Vardenafil Impurity 47 (CAS 910554-78-8)
- Nadifloxacin Impurity 1 (CAS 131190-82-4)
- Procaine Impurity 20 (CAS CATO-C4X-262320)
- Clevidipine butyrate Impurity 12 (CAS 91854-03-4)
- 4,6-Dihydro-1H,3H-furo[3,4-c]furan-1,3-dione-d4 (CAS 1643544-03-9)
- Methyl 4,4-difluoropiperidine-3-carboxylate hydrochloride (CAS 1784863-98-4)
- N-(2-Fluoroethyl)pyridin-4-amine (CAS 122974-87-2)
- Cyproheptadine Impurity 2 (CAS 2222-33-5)
- (4-(4-Bromopyridin-2-yl)furan-2-yl)boronic acid (CAS 2225176-88-3)
- 6-(4-Methoxyphenyl)piperidine-2-carboxylic acid (CAS 1137663-98-9)
- Thymopoietin II Peptide Fragment (CAS 56795-64-3)
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