Roflumilast Impurity 45 CAS CATO-C4X-108445
| CAS No. | CATO-C4X-108445 |
| Molecular Formula | C14H16F2O3S |
| Molecular Weight | 302.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Roflumilast Impurity 45 (CAS CATO-C4X-108445, C14H16F2O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Roflumilast Impurity 45 (C14H16F2O3S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 302.34 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Roflumilast Impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H16F2O3S |
| Molecular Weight | 302.34 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Roflumilast Standards
- Roflumilast Impurity 56 (CAS CATO-C4X-108456)
- Roflumilast Impurity C51 (CAS 1412448-29-3)
- Roflumilast Impurity 52 (CAS CATO-C4X-108452)
- Roflumilast Impurity 49 (CAS CATO-C4X-108449)
- Roflumilast Impurity 50 (CAS 1180526-15-1)
- Roflumilast Impurity 55 (CAS CATO-C4X-108455)
- Roflumilast impurity 20 (CAS 2206113-97-3)
- Roflumilast Impurity 42 (CAS CATO-C4X-108442)
Recommended Standards
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