Roflumilast Impurity 52 CAS CATO-C4X-108452
| CAS No. | CATO-C4X-108452 |
| Molecular Formula | C12H11ClF2O4 |
| Molecular Weight | 292.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 292.66 g/mol gives Roflumilast Impurity 52 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Roflumilast Impurity 52 (CAS CATO-C4X-108452) is a certified pharmaceutical impurity reference standard with the molecular formula C12H11ClF2O4 and a molecular weight of 292.66 g/mol.
The molecular framework of Roflumilast Impurity 52 (C12H11ClF2O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Roflumilast Impurity 52 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H11ClF2O4 |
| Molecular Weight | 292.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
Related Roflumilast Standards
- Roflumilast Impurity 49 (CAS CATO-C4X-108449)
- Roflumilast Impurity 50 (CAS 1180526-15-1)
- Roflumilast Impurity C51 (CAS 1412448-29-3)
- Roflumilast Impurity 45 (CAS CATO-C4X-108445)
- Roflumilast Impurity 56 (CAS CATO-C4X-108456)
- Roflumilast Impurity 55 (CAS CATO-C4X-108455)
- Roflumilast Impurity 58 (CAS CATO-C4X-193558)
- Roflumilast impurity 15 (CAS 162401-69-6)
Recommended Standards
- 5-Chloro-4-fluoro-2-(4-fluorophenyl)benzofuran-3-carbaldehyde (CAS 1449332-86-8)
- N-(3-chloro-2-fluorophenyl)-3-cyano-5-fluorobenzamide (CAS 1243310-20-4)
- 3-(4-Chloro-2-fluoro-5-methylphenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole (CAS 142623-48-1)
- 2-(2-Chlorophenyl)-6,7-difluoroquinazolin-4(3H)-one (CAS 1361457-75-1)
- Folic Acid EP Impurity E (CAS 1391068-26-0)
- Sitafloxacin impurity 78 (CAS CATO-C4X-115578)
- Drotaverine Impurity 18 (CAS 27472-20-4)
- Cyclopentanecarboximidamide hydrochloride (CAS 68284-02-6)
- 5α-Androst-9(11)-ene-3,17-dione (CAS 15375-19-6)
- (2S,5R)-5-Methylpyrrolidine-2-carboxylic acid (CAS 38228-16-9)
- 3-[(Tetrahydro-2H-pyran-2-yl)oxy]-1-butanol (CAS 40595-23-1)
- 3-(Benzo[d][1,3]dioxol-5-yl)pentan-3-ol (CAS 35533-73-4)
- Dichlorprop Dimethylammonium Salt (CAS 53404-32-3)
- Semaglutide Impurity 191 (CAS CATO-C4X-2226191)
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