Roflumilast Impurity 44 CAS CATO-C4X-108444
| CAS No. | CATO-C4X-108444 |
| Molecular Formula | C12H13F2NO3 |
| Molecular Weight | 257.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Roflumilast Impurity 44 (C12H13F2NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Roflumilast Impurity 44 (CAS CATO-C4X-108444) is a certified pharmaceutical impurity reference standard with the molecular formula C12H13F2NO3 and a molecular weight of 257.23 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Roflumilast Impurity 44 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H13F2NO3 |
| Molecular Weight | 257.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Roflumilast Standards
- Roflumilast impurity 15 (CAS 162401-69-6)
- Roflumilast Impurity 33 (CAS 2376345-94-5)
- Roflumilast Impurity 34 (CAS 1882067-44-8)
- Roflumilast USP Related Compound D (CAS 162401-62-9)
- Roflumilast Impurity C65 (CAS 162401-60-7)
- Roflumilast Impurity 58 (CAS CATO-C4X-193558)
- Roflumilast Impurity 43 (CAS CATO-C4X-108443)
- Roflumilast impurity 23 (CAS 1369817-76-4)
Recommended Standards
- tert-Butyl (2,4-difluoro-3-formylphenyl)carbamate (CAS 701269-22-9)
- 4'-Methyl-5-nitro-[1,1'-biphenyl]-3-carboxylic acid (CAS 1000587-29-0)
- N-(4-ethynylphenyl)-2,6-difluorobenzamide (CAS 439095-46-2)
- Methyl 3-aminodibenzo[b,e][1,4]dioxine-1-carboxylate (CAS 1011407-42-3)
- Crisaborole Impurity 147 (CAS CATO-C4X-2021147)
- Valsartan Impurity 32 (CAS CATO-C4X-105732)
- Saxagliptin Impurity 13 (CAS CATO-C4X-104913)
- Ethyl 6-(4-heptyloxyphenyl)-6-oxohexanoate (CAS 898757-99-8)
- 1,4-Dimethyl-2-(4-phenylbutoxy)benzene (CAS 500904-64-3)
- tert-Butyl 2,5-diazaspiro[3.4]octane-2-carboxylate (CAS 1086398-02-8)
- N-(1H-Indol-4-ylmethyl)-N-(tetrahydrofuran-2-ylmethyl)amine (CAS 944897-13-6)
- 1-(2,6-Dichlorobenzyl)-N-methoxy-6-oxo-1,6-dihydropyridine-3-carboxamide (CAS 400086-04-6)
- (1S,2R)-1-amino-1-(thiophen-3-yl)propan-2-ol (CAS 1213180-73-4)
- Cholecystokinin Octapeptide (1-3) (desulfated) H-Asp-Tyr-Met-OH (CAS 121880-94-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com