Tadalafil Impurity 80 CAS CATO-C4X-108780

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-108780
Molecular FormulaC21H16Cl2N2O5
Molecular Weight447.27 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Tadalafil Impurity 80 CAS CATO-C4X-108780 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 447.27 g/mol gives Tadalafil Impurity 80 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Tadalafil Impurity 80 (CAS CATO-C4X-108780) is a certified pharmaceutical impurity reference standard with the molecular formula C21H16Cl2N2O5 and a molecular weight of 447.27 g/mol.

Tadalafil Impurity 80 (C21H16Cl2N2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

CATO manufactures Tadalafil Impurity 80 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

Molecular FormulaC21H16Cl2N2O5
Molecular Weight447.27 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity>95%
StorageStore in a cool place (≤25°C), protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)14.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
Halogen ContentCl-containing
Nitrogen Atoms2

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