Ticagrelor Impurity 66 HCl CAS CATO-C4X-109366
| CAS No. | CATO-C4X-109366 |
| Molecular Formula | C9H9F2N |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Ticagrelor Impurity 66 HCl (CAS CATO-C4X-109366, C9H9F2NHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution, Ticagrelor Impurity 66 HCl is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 205.63 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H9F2N HCl |
| Molecular Weight | 205.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Ticagrelor Standards
- Ticagrelor Impurity N40 (CAS 1006376-60-8)
- Ticagrelor Impurity 88 (CAS 1006376-61-9)
- Ticagrelor Impurity 152 (CAS 1006376-62-0)
- Ticagrelor Impurity 121 (CAS 1006614-49-8)
- Ticagrelor impurity 84（trans） (CAS 1006614-51-2)
- Ticagrelor Impurity 113 (CAS 1156575-52-8)
- Ticagrelor impurity 161 (CAS 1157692-93-7)
- Ticagrelor Impurity 168 (CAS 1207276-00-3(free base))
Recommended Standards
- Flucloxacillin EP Impurity B (Mixture of Diastereomers) (CAS 1276016-89-7)
- Fluticasone Furoate EP Impurity I (CAS 3086156-07-9)
- Glycerol Impurity 36 (CAS 14180-03-1)
- 2-Oxepanone, polymer with 4-amino-.alpha.,.alpha.,4-trimethylcyclohexanemethanamine, 1,6-hexanediol, 2,2'-iminobis[ethanol], 1,1'-methylenebis[4-isocyanatocyclohexane] and 2,2'-oxybis[ethanol] (CAS 68052-62-0)
- Perfluoroethylsulphonyl Chloride (CAS 64773-40-6)
- N-(pyridin-2-ylmethyl)piperidin-4-amine (CAS 1184521-60-5)
- tert-Butyl (1-carbamoylcyclopentyl)carbamate (CAS 223648-38-2)
- Coriaria Lactone (CAS 2571-22-4)
- 3-(Furan-2-yl)-N-isopropylacrylamide (CAS 22111-23-5)
- Tau Peptide (298-312) trifluoroacetate salt (CAS 330456-47-8)
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