Amlodipine 131 CAS CATO-C4X-1095131
| CAS No. | CATO-C4X-1095131 |
| Molecular Formula | C22H27ClN2O7 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Amlodipine 131 (C22H27ClN2O7HCl) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Amlodipine 131 (CAS CATO-C4X-1095131, C22H27ClN2O7HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H27ClN2O7 HCl |
| Molecular Weight | 503.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Amlodipine Standards
- Amlodipine Impurity N32 (CAS 103094-30-0)
- (R)-Amlodipine (CAS 103129-81-3)
- Amlodipine (S)-Isomer (CAS 103129-82-4)
- Amlodipine Impurity N5 (CAS 107812-86-2)
- Amlodipine Impurity N2 (CAS 111429-90-4)
- Amlodipine Besylate (CAS 111470-99-6)
- Amlodipine Impurity N4 (CAS 113994-36-8)
- Amlodipine Impurity 38 (CAS 113994-37-9)
Recommended Standards
- Eldecalcitol Impurity 81 (CAS CATO-C4X-214081)
- Clonazepam Impurity 5 (CAS 17714-02-2)
- Ketorolac Impurity 78 (CAS CATO-C4X-166978)
- 1-Hydroxy-4-methyl-1,3-dihydrobenzo[c][1,2]oxaborole (CAS 947162-74-5)
- 3-Isobutoxy-4-methylbenzaldehyde (CAS 1379222-07-7)
- Methyl (4,6-dimethoxypyrimidin-2-yl)propanoate (CAS 870079-64-4)
- (5-Methyl-3-nitropyridin-2-yl)methanamine (CAS 1824304-31-5)
- Pyrrolidin-1-amine hydrochloride (CAS 63234-71-9)
- Naproxen Impurity 18 (CAS 2601735-81-1)
- Insulin Degludec Impurity 26 (CAS CATO-C4X-215726)
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