Ezetimibe Impurity 76 CAS CATO-C4X-109876
| CAS No. | CATO-C4X-109876 |
| Molecular Formula | C17H14F2O2 |
| Molecular Weight | 288.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Ezetimibe Impurity 76 (CAS CATO-C4X-109876), a pharmacopoeial impurity reference standard (molecular formula C17H14F2O2, MW 288.29 g/mol) used for the identification and quantification of trace impurities in APIs.
Ezetimibe Impurity 76 (C17H14F2O2) contains a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H14F2O2 |
| Molecular Weight | 288.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Ezetimibe Standards
- Ezetimibe Impurity 131 (CAS CATO-C4X-1098131)
- Ezetimibe Impurity N49 (CAS 1056188-47-6)
- Ezetimibe Impurity 98 (CAS CATO-C4X-109898)
- Ezetimibe Impurity 145 (Z-Isomer) (CAS CATO-C4X-1098145)
- Ezetimibe Impurity 35 (CAS 70627-52-0)
- Ezetimibe Impurity 114 (CAS CATO-C4X-1098114)
- Ezetimibe Impurity 28 (CAS CATO-C4X-109828)
- Ezetimibe Impurity 62 (CAS 1618657-31-0)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com