Neratinib Impurity 25 CAS 848133-87-9
| CAS No. | 848133-87-9 |
| Molecular Formula | C12H10ClN3O |
| Molecular Weight | 247.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 247.68 g/mol gives Neratinib Impurity 25 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Neratinib Impurity 25 (CAS 848133-87-9, C12H10ClN3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Neratinib Impurity 25 (C12H10ClN3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Neratinib Impurity 25 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H10ClN3O |
| Molecular Weight | 247.68 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Neratinib Standards
- Neratinib Impurity 51 (CAS CATO-C4X-113451)
- Neratinib Impurity 52 (CAS CATO-C4X-113452)
- Neratinib Impurity 43 (CAS 1222172-49-7)
- Neratinib Impurity 60 (CAS CATO-C4X-113460)
- Neratinib Impurity 58 (CAS CATO-C4X-113458)
- Neratinib Impurity 41 (CAS 1201080-20-7)
- Neratinib Impurity 23 (CAS 524955-09-7)
- Neratinib Impurity 55 (CAS CATO-C4X-113455)
Recommended Standards
- (E)-N-{[2-(4-chlorophenoxy)phenyl]methylidene}hydroxylamine 12N-028 449778-56-7 (CAS 449778-56-7)
- Chlorphenamine impurity 52 (CAS CATO-C4X-118852)
- Phenyl (4-chlorophenyl)carbamate (CAS 50882-28-5)
- Quetiapine Impurity 61 (CAS 65141-02-8)
- Cabozantinib Impurity 5 (CAS 849217-60-3)
- Crisaborole lmpurity 89 (CAS 1187187-13-8)
- Pemetrexed Impurity 51 (CAS CATO-C4X-172651)
- 2-Amino-5-(difluoromethyl)-6-iodonicotinonitrile (CAS 1803698-86-3)
- Methyl Morpholine-4-carboxylate (CAS 6906-13-4)
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- 1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine (CAS 879132-46-4)
- 4-[4-(propan-2-yl)-1,3-thiazol-2-yl]piperidine dihydrochloride (CAS 1269151-99-6)
- (3S,5S)-3,5-difluoropiperidine;hydrochloride (CAS 2742623-56-7)
- Crustacean Cardioactive Peptide (CCAP) (CAS 309247-84-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com