Aprepitant Impurity 37 CAS CATO-C4X-114137
| CAS No. | CATO-C4X-114137 |
| Molecular Formula | C12H7F9O2 |
| Molecular Weight | 354.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 354.17 g/mol gives Aprepitant Impurity 37 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Aprepitant Impurity 37 (CAS CATO-C4X-114137, C12H7F9O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, Aprepitant Impurity 37 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 354.17 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H7F9O2 |
| Molecular Weight | 354.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Aprepitant Standards
- Aprepitant Impurity 31 (CAS 2410426-96-7)
- Aprepitant impurity 36 (CAS CATO-C4X-237936)
- Aprepitant impurity 35 (CAS 395683-22-4)
- Aprepitant impurity 31 (CAS 657419-48-2)
- Aprepitant Impurity 39 (CAS 176306-78-8)
- Aprepitant Impurity 36 (CAS 638990-20-2)
- Aprepitant Impurity 72 (CAS 502537-07-7)
- Aprepitant Impurity 26 (CAS CATO-C4X-116826)
Recommended Standards
- 2-Chloro-1-(5-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)thiophen-2-yl)ethan-1-one (CAS 338411-65-7)
- 4-(5,6-Dichloro-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl)benzoic acid (CAS 1005057-07-7)
- 2-Bromo-N-[4-(2-fluorobenzoyl)-1,3-dimethyl-1H-pyrazol-5-yl]-acetamide (CAS 63960-69-0)
- 2-(4-(2-(2,4-Dichlorophenoxy)acetamido)phenyl)acetic acid (CAS 1012207-68-9)
- Dabigatran Impurity 106 (CAS CATO-C4X-1089106)
- Pemetrexed Impurity 25 (CAS CATO-C4X-172625)
- Isoconazole Impurity 7 (CAS 27523-05-3)
- 2-(Benzylthio)-4-chlorobenzoic Acid Chloride (CAS 40183-55-9)
- 4-Methylumbelliferyl 2-acetamido-3-4-6-tri-O-acetyl-2-deoxy-β-D-galactopyranoside (CAS 124167-46-0)
- Ethenyldisulfanylethene (CAS 15805-34-2)
- 6,7-Dihydroxyisoquinoline-3-carboxamide (CAS 146515-42-6)
- Mitiglinide impurity 24 (CAS CATO-C4X-116124)
- 5-methylpyridazin-3(2H)-one (CAS 54709-94-3)
- Bax inhibitor peptide V5 (CAS 579492-81-2)
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