Aprepitant Impurity 26 CAS CATO-C4X-116826
| CAS No. | CATO-C4X-116826 |
| Molecular Formula | C20H17F6NO2 |
| Molecular Weight | 417.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Aprepitant Impurity 26 (CAS CATO-C4X-116826, C20H17F6NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Aprepitant Impurity 26 (C20H17F6NO2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Aprepitant Impurity 26 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H17F6NO2 |
| Molecular Weight | 417.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant Impurity 22 (CAS 934540-48-4)
- Aprepitant Impurity 48 (CAS 380499-07-0)
- Aprepitant impurity 01 (CAS 171338-27-5)
- Aprepitant Impurity 41 (CAS CATO-C4X-114141)
- Aprepitant Impurity 43 (CAS CATO-C4X-114143)
- Aprepitant Impurity 30 (CAS 172678-47-6)
- Aprepitant Impurity 36 (CAS 638990-20-2)
- Aprepitant impurity 31 (CAS 657419-48-2)
Recommended Standards
- N-(4-nitrophenyl)-4-((2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)methyl)benzamide (CAS 339025-38-6)
- Ne-POC PMPA Tenofovir Impurity B (CAS 1246812-16-7)
- 4-Bromo-3,5-dimethyl-1-trityl-1H-pyrazole (CAS 919802-98-5)
- tert-Butyl 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)methyl)piperidine-1-carboxylate (CAS 1310383-45-9)
- Cholic Acid Impurity 39 (CAS CATO-C4X-116039)
- Brexpiprazole Impurity 43 (CAS 1420987-85-4)
- Lincomycin Impurity 29 (CAS CATO-C4X-134229)
- Methyl 2-(4-chlorophenyl)-2,2-difluoroacetate (CAS 1393558-32-1)
- 4-Cyclopropoxy-N,N,6-trimethylpicolinamide (CAS 1243317-82-9)
- 5,7-bis(trifluoromethyl)-N-[3-(trifluoromethyl)phenyl][1,8]naphthyridin-2-amine (CAS 241488-36-8)
- (R)-5-((Methylthio)methyl)piperazin-2-one (CAS 1240590-56-0)
- Methyl 5-(aminomethyl)bicyclo[3.2.1]Octane-1-carboxylate hydrochloride (CAS 2198519-29-6)
- 2-((4-((2-Hydroxybenzyl)amino)phenyl)thio)-N-(3-nitrophenyl)acetamide (CAS 763108-19-6)
- Insulin Degludec Impurity 26 (CAS CATO-C4X-215726)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com