rac-Aprepitant-d4 (and enantiomer) CAS CATO-C4X-114140
| CAS No. | CATO-C4X-114140 |
| Molecular Formula | - |
| Molecular Weight | 538.45 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies rac-Aprepitant-d4 (and enantiomer) (CAS CATO-C4X-114140), a certified reference material (molecular formula C23H17D4F7N4O3, MW 538.45 g/mol) for analytical method development and quality control.
Owing to deuterium isotope labeling, a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, rac-Aprepitant-d4 (and enantiomer) is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 538.45 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), rac-Aprepitant-d4 (and enantiomer) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H17D4F7N4O3 |
| Molecular Weight | 538.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related rac Standards
- Aprepitant D4 (CAS 1133387-60-6)
- Aprepitant-13C2,d2 (Major) (CAS 1217676-37-3)
- Aprepitant (CAS 170729-80-3)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Aprepitant Impurity 3 (CAS 172822-28-5)
- Aprepitant Impurity 4 (CAS 172822-29-6)
- Aprepitant Impurity 5 (CAS 1242175-40-1)
Recommended Standards
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